Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
Groutas, William C.
Saif, Linda J.
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Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C; Hua, Duy; Saif, Linda J., inventors. Kansas State University Research Foundation (Manhattan, KS), The Ohio State University (Columbus, OH), Wichita State University (Wichita, KS), assignees. Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses. United States patent US 9,474,759. 2016, Oct 25.
Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.
WSU inventor: Groutas, William C., Dept. of Chemistry, College of Liberal Arts and Sciences.
Application No.: 14/347,756 filed September 27, 2012. Patent No.: US 9,474,759 granted October 25, 2016.