Recent Submissions

  • Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses 

    Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C. (United States Patent and Trademark Office, 2016-04-12)
    Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ...
  • End effector for forming swept friction stir spot welds 

    Burford, Dwight A. (United States Patent and Trademark Office, 2015-09-15)
    An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder.
  • Protective antigen having fluorinated histidine residues 

    Bann, James G. (United States Patent and Trademark Office, 2010-06-08)
    The unnatural amino acid analogue 2-fluorohistidine (2-FHis) was incorporated into protective antigen to produce a protein which resists protonation at physiological pH by reducing the side-chain pKa. The protein structure ...
  • System and method for capturing image sequences at ultra-high framing rates 

    Madhavan, Viswanathan; Hijazi, Ala (United States Patent and Trademark Office, 2010-08-17)
    An imaging system for capturing a sequence of images from a target at ultra-high framing rates is disclosed. The imaging system includes an illumination system operable to emit at least first and second light pulses at ...
  • Latent isocynate derivatives useful for deactivating enzymes 

    Groutas, William C. (United States Patent and Trademark Office, 1990-05-29)
    Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ...
  • Viral and fungal inhibitors 

    Padmanabhan, Radhakrishnan; Groutas, William C.; Korba, Brent E (United States Patent and Trademark Office, 2013-08-20)
    Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ...
  • Friction stir welding tool having a counterflow pin configuration 

    Burford, Dwight A. (United States Patent and Trademark Office, 2011-05-17)
    A friction stir welding tool having one or more tapered flats for promoting flow of weld material toward the pin terminus and one or more counter-spiraling channels or threads which for promoting flow of the weld material ...
  • Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes 

    Groutas, William C. (United States Patent and Trademark Office, 2002-12-17)
    Compounds of the general formula I are provided: ##STR1## and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R.sub.i capable of binding at a primary specificity site of a protease; Y is a ...
  • Serine protease inhibitors 

    Groutas, William C. (United States Patent and Trademark Office, 1996-08-27)
    Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents.
  • 1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives 

    Groutas, William C.; Kuang, Rongze (United States Patent and Trademark Office, 2002-07-16)
    Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
  • Friction stir welding tool having a scroll-free concentric region 

    Burford, Dwight A. (United States Patent and Trademark Office, 2011-09-13)
    A friction stir welding tool having a shoulder section with a scroll pattern that terminates prior to the edge or boundary of the shoulder section to create a scroll-free concentric surface area.
  • End effector for forming swept friction stir spot welds 

    Burford, Dwight A. (United States Patent and Trademark Office, 2013-05-21)
    An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder.
  • Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films 

    Dowling, Matthew; Raghavan, Srinivasa R.; Dashaputre, Neeraja; English, Douglas S.; Javvaji, Vishal; Payne, Gregory F.; DeShong, Philip R. (United States Patent and Trademark Office, 2014-10-14)
    A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle ...
  • Energy absorbing seat mechanism 

    Olivares, Gerardo (United States Patent and Trademark Office, 2016-05-03)
    A system includes a shear member and an energy absorber. The shear member is configured to couple a seat portion to a base structure of a vehicle. The shear member is configured to sustain a first load without fracture and ...
  • Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses 

    Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C.; Hua, Duy; Saif, Linda J. (United States Patent and Trademark Office, 2016-10-25)
    Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the ...