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  • Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses 

    Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C. (United States Patent and Trademark Office, 2016-04-12)
    Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ...
  • End effector for forming swept friction stir spot welds 

    Burford, Dwight A. (United States Patent and Trademark Office, 2015-09-15)
    An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder.
  • Protective antigen having fluorinated histidine residues 

    Bann, James G. (United States Patent and Trademark Office, 2010-06-08)
    The unnatural amino acid analogue 2-fluorohistidine (2-FHis) was incorporated into protective antigen to produce a protein which resists protonation at physiological pH by reducing the side-chain pKa. The protein structure ...
  • System and method for capturing image sequences at ultra-high framing rates 

    Madhavan, Viswanathan; Hijazi, Ala (United States Patent and Trademark Office, 2010-08-17)
    An imaging system for capturing a sequence of images from a target at ultra-high framing rates is disclosed. The imaging system includes an illumination system operable to emit at least first and second light pulses at ...
  • Latent isocynate derivatives useful for deactivating enzymes 

    Groutas, William C. (United States Patent and Trademark Office, 1990-05-29)
    Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ...
  • Viral and fungal inhibitors 

    Padmanabhan, Radhakrishnan; Groutas, William C.; Korba, Brent E (United States Patent and Trademark Office, 2013-08-20)
    Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ...
  • Friction stir welding tool having a counterflow pin configuration 

    Burford, Dwight A. (United States Patent and Trademark Office, 2011-05-17)
    A friction stir welding tool having one or more tapered flats for promoting flow of weld material toward the pin terminus and one or more counter-spiraling channels or threads which for promoting flow of the weld material ...
  • Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes 

    Groutas, William C. (United States Patent and Trademark Office, 2002-12-17)
    Compounds of the general formula I are provided: ##STR1## and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R.sub.i capable of binding at a primary specificity site of a protease; Y is a ...
  • Serine protease inhibitors 

    Groutas, William C. (United States Patent and Trademark Office, 1996-08-27)
    Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents.
  • 1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives 

    Groutas, William C.; Kuang, Rongze (United States Patent and Trademark Office, 2002-07-16)
    Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
  • Friction stir welding tool having a scroll-free concentric region 

    Burford, Dwight A. (United States Patent and Trademark Office, 2011-09-13)
    A friction stir welding tool having a shoulder section with a scroll pattern that terminates prior to the edge or boundary of the shoulder section to create a scroll-free concentric surface area.
  • End effector for forming swept friction stir spot welds 

    Burford, Dwight A. (United States Patent and Trademark Office, 2013-05-21)
    An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder.
  • Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films 

    Dowling, Matthew; Raghavan, Srinivasa R.; Dashaputre, Neeraja; English, Douglas S.; Javvaji, Vishal; Payne, Gregory F.; DeShong, Philip R. (United States Patent and Trademark Office, 2014-10-14)
    A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle ...
  • Energy absorbing seat mechanism 

    Olivares, Gerardo (United States Patent and Trademark Office, 2016-05-03)
    A system includes a shear member and an energy absorber. The shear member is configured to couple a seat portion to a base structure of a vehicle. The shear member is configured to sustain a first load without fracture and ...
  • Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses 

    Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C.; Hua, Duy; Saif, Linda J. (United States Patent and Trademark Office, 2016-10-25)
    Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the ...
  • Multi-scale characterization of an adhesive bondline with fabrication induced defects 

    Fang, Eugene; Lua, Jim; Zhang, Yongjie Jessica; Lai, Yicong; Seneviratne, Waruna P. (DEStech Publications, Inc., 2015)
    A multiscale characterization of an adhesive bondline is performed to investigate the fabrication defects dependent failure mechanisms of an I-beam under four point bending. To obtain a realistic representative volume of ...
  • ACG MTM45-1: Material Model Development Final Project Wrap-Up 

    Shahkarami, A.; Van Ee, D. (Wichita State University. National Institute for Aviation Research, 2009-11-15)
    National Center for Advanced Material Performance document prepared by: A. Shahkarami and D. Van Ee. Reviewed by: D. Van Ee Approved: A.Poursartip. Date: November 15th, 2009 Version: 1.0
  • The use of neural network and discrete Fourier transform for real-time evaluation of friction stir welding 

    Boldsaikhan, Enkhsaikhan; Corwin, Edward M.; Logar, Antonette M.; Arbegast, William J. (Elsevier, 2011-12)
    This paper introduces a novel real-time approach to detecting wormhole defects in friction stir welding in a nondestructive manner. The approach is to evaluate feedback forces provided by the welding process using the ...
  • Performance evaluation of child safety seats in far-side lateral sled tests at varying speeds 

    Ghati, Yoganand; Menon, Rajiv A.; Milone, Mary; Lankarani, Hamid M.; Olivares, Gerardo (Association for the Advancement of Automotive Medicine, 2009-10-05)
    Protection of children in Child Safety Seats (CSS) in side impact crashes has been a topic of recent studies. The objective of this study was to evaluate the performance of CSS in far-side impacts through a series of sled ...
  • SPH -- Lagrangian study of bird impact on leading edge wing 

    Guida, M.; Marulo, F.; Meo, M.; Grimaldi, A.; Olivares, Gerardo (Elsevier, 2011-02)
    Results from the experimental tests are given so that they can be used to validate numerical models and promote the use of the numerical tools in aircraft design and certification process. The explicit finite element ...