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Browsing by Subject "Mutation"

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Characterization of mutations at the mouse phenylalanine hydroxylase locus

McDonald, J. David; Charlton, Cynthia K. (Academic Press, 1997-02-01)

Two genetic mouse models for human phenylketonuria have been characterized by DNA sequence analysis. For each, a distinct mutation was identified within the protein coding sequence of the phenylalanine hydroxylase gene. ...
Characterization of the mouse phenylalanine hydroxylase mutation Pah(enu3)

Haefele, Mark J.; White, Gabriele; McDonald, J. David (Academic Press, 2001-01)

Phenylketonuria (PKU) is an inborn error of metabolism that is inherited in an autosomal recessive manner. It arises from a deficiency of phenylalanine hydroxylase, which is responsible for converting phenylalanine to ...
ENU mutagenesis in the mouse

McDonald, J. David; Beier, David (John Wiley & Sons, 2004-02)

This unit describes the treatment of laboratory mice with the mutagen N-ethyl-N-nitrosourea (ENU) to achieve very highly induced rates of mutation throughout the genome. Further, it describes several popular mating schemes ...
Evaluation of the genotoxic spectrum of cisplatin for Candida albicans

Sarachek, Alvin; Henderson, Lori A.; Wilkens, W. E. (University of Cambridge * Faculty Press, 1992)

The platinum co-ordination complex cisplatin [cis-diamminedichloroplatinum (II)] is a highly effective anticancer drug whose activity derives from its ability to form adducts crosslinking neighbouring purine bases in DNA. ...
Hormone-specific inhibitory influence of alpha-subunit Asn56 oligosaccharide on in vitro subunit association and follicle-stimulating hormone receptor binding of equine gonadotropins

Butnev, Viktor Y.; Gotschall, R. Russell; Butnev, Vladimir Y.; Baker, Vanda L.; Moore, William T.; Bousfield, George R. (Society for the Study of Reproduction, 1998-02-01)

Hybrid hormones were created using combinations of equine (e) LH, eFSH, and eCG alpha- and beta-subunit preparations. The efficiency of eFSH beta association was highest with eLH alpha (64-72%) and was lowest with eCG alpha ...
Linkage analysis of the hph-1 mutation and the GTP cyclohydrolase I structural gene

Montañez, Cindy S.; McDonald, J. David (Academic Press, 1999-09)

Our research establishes genetic linkage between the hph-1 mutation and the GTP-CH I structural gene. Our results indicate that these two loci are within an 8 cM region with 95% confidence. This finding lends additional ...
Recombinagenicity of caffeine for Candida albicans

Sarachek, Alvin; Henderson, Lori A. (SpringerSpringer Netherlands, 1990-05)

Caffeine at concentrations of 0.5 x 10(-2) M or higher inhibited cell replication and induced gene segregations in Candida albicans cultured on defined complete medium. Both responses increased incrementally with increasing ...
Speculation on the genetic origin of cultural behavior: a key mutation for asymmetry

D'Agostino, Anthony (Lambda Alpha Anthropology Honors Society at Wichita State University, 1984)

The most basic elements of culture which separate humans from other animals are the efficient use of tools and the development of language. Evidence is presented suggesting that a key mutation for lateral dominance ...

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